Modest-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/nine) induce a lytic sort of cell death referred to as pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/nine inhibition activates the inflammasome sensor Nlrp1b, which in turn activates Professional-caspase-1 to mediate cell death3, eve… Read More

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